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Search Results to Vladimir Lupashin

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Lupashin, Vladimir

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Our laboratory is interested in understanding the molecular mechanisms responsible for the generation and maintenance of intra-cellular membrane-bounded compartments. In all eukaryotic cells intracellular membrane trafficking is critical for a range of important cellular functions including protein secretion, post-translational modifications, cell signalling, cell polarization, and cell maintenance. Defects in membrane trafficking can underline, or even exacerbate, a number of human diseases including cancer, diabetes mellitus, Alzheimer’s, cystic fibrosis, Hermansky-Pudlak syndrome and Congenital Disorders of Glycosylation. Our research directed towards the understanding of the basic mechanisms of intracellular vesicular trafficking using both yeast and mammalian tissue culture cell model systems. Our lab played a principal role in the discovery of a novel vesicle tethering factors, published more than 60 original papers in high-profile journals, including Journal of Cell Biology, PNAS, Science, Journal of Neuroscience, Molecular Biology of Cell and Nature Communications. My current research has been continuously supported by grants from both NSF and NIH. We have pioneered the functional analysis of the Conserved Oligomeric Golgi (COG), an evolutionarily conserved complex of eight gene products, each of which is critical for the membrane trafficking and protein modifications in the Golgi apparatus. The COG complex interacts with core fusion machinery components including SNAREs, SM proteins, Rabs, coiled-coil tethers and COPI coat to organize specific docking and fusion of transport intermediates with their acceptor membrane. By using state of the art biochemical, genetic and microscopy approaches (including mass-spectrometry, electron and super-resolution microscopy, CRISPR directed gene editing techniques) we would like to determine how the key components of intracellular membrane trafficking machinery work together to direct efficient protein trafficking in human cells in health and disease.

One or more keywords matched the following items that are connected to Lupashin, Vladimir

Item Type	Name
Academic Article	Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex.
Academic Article	Role of tethering factors in secretory membrane traffic.
Academic Article	[The nature of N-terminal signal sequence determines the type of intracellular distribution and effectiveness of export of human growth hormone in Saccharomyces cerevisiae].
Academic Article	[Localization of acid phosphatase in Saccharomyces cerevisiae and its export into culture media depends on the type of the N-terminal signal peptide].
Academic Article	Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter.
Academic Article	Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation.
Academic Article	Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells.
Academic Article	Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.
Academic Article	The COG complex, Rab6 and COPI define a novel Golgi retrograde trafficking pathway that is exploited by SubAB toxin.
Academic Article	Oxysterol-binding protein (OSBP) is required for the perinuclear localization of intra-Golgi v-SNAREs.
Academic Article	COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation.
Academic Article	Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic.
Academic Article	COG complexes form spatial landmarks for distinct SNARE complexes.
Academic Article	Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene.
Academic Article	Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.
Academic Article	Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking.
Academic Article	COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.
Academic Article	t-SNARE activation through transient interaction with a rab-like guanosine triphosphatase.
Academic Article	Mislocalization of large ARF-GEFs as a potential mechanism for BFA resistance in COG-deficient cells.
Academic Article	Assembly of the ER to Golgi SNARE complex requires Uso1p.
Academic Article	[A new secreted protein from Saccharomyces cerevisiae, stimulated by heat shock].
Academic Article	Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p.
Academic Article	Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF).
Academic Article	The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins.
Concept	Protein Subunits
Concept	Protein Conformation
Concept	Protein Processing, Post-Translational
Concept	Protein Structure, Quaternary
Concept	Protein Binding
Concept	Protein Transport
Concept	Protein Interaction Maps
Concept	Protein Multimerization
Concept	Protein Stability
Concept	Protein Structure, Secondary
Concept	Coat Protein Complex I
Concept	Protein Structure, Tertiary
Concept	Protein Sorting Signals
Concept	Structural Homology, Protein
Academic Article	Mini-Review: Role of the Conserved Oligomeric Golgi (COG) complex in protein glycosylation
Academic Article	The COG Complex-mediated Docking of intra-Golgi Vesicles is Essential for Normal Protein Glycosylation
Academic Article	The COG complex interacts with the t-SNARE Syntaxin5 to direct trafficking of recyling intra-Golgi vesicles that is essential for normal protein glycosylation
Academic Article	Serotonin Regulates the Plasma Membrane Expression of Serotonin Transporter Protein Via its Interactions with Rab4
Academic Article	The COG Complex-mediated Recyling of Golgi Enzymes is Essential for Normal Protein Glycosylation
Academic Article	Macromolecules in functioning cell
Academic Article	Protein Trafficking: Mechanisms and Regulations
Academic Article	The role of glycosylation in protein secretion
Academic Article	Optimal conditions for homologic and heterologic protein export by S. cerevisiae
Academic Article	Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex.
Academic Article	Expression of functional Myc-tagged conserved oligomeric Golgi (COG) subcomplexes in mammalian cells.
Academic Article	COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex.
Academic Article	Creating Knockouts of Conserved Oligomeric Golgi Complex Subunits Using CRISPR-Mediated Gene Editing Paired with a Selection Strategy Based on Glycosylation Defects Associated with Impaired COG Complex Function.
Academic Article	A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication.
Academic Article	Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking.
Academic Article	The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors.
Academic Article	Membrane detachment is not essential for COG complex function.
Academic Article	More than just sugars: Conserved oligomeric Golgi complex deficiency causes glycosylation-independent cellular defects.
Academic Article	Detailed Analysis of the Interaction of Yeast COG Complex.
Grant	Super-Resolution Light Microscope at University of Arkansas for Medical Sciences
Grant	Characterization of mammalian COG complex-interacting Golgi trafficking machinery
Grant	Structural and functional analysis of SEC 34 Protein complex
Academic Article	Golgi inCOGnito: From vesicle tethering to human disease.
Academic Article	Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma.
Academic Article	The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery.
Academic Article	Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System.
Academic Article	A Rab33b missense mouse model for Smith-McCort dysplasia shows bone resorption defects and altered protein glycosylation.

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